Background: It has been reported that statins therapy can up-regulate PSCK9 expression,
which might be associated with the “6% rule” of statins. Additionally, previous data indicated that
the extended-release statin could greatly reduce the exposure of statin in circulation. However,
whether extended-release statin has less effect on serum PCSK9 level is completely unknown.
Methods: In this randomized, controlled, open-label, prospective study, 61 patients who had not
receive any lipid-lowering drugs before were enrolled and assigned to the three groups: immediaterelease
fluvastatin 40mg/d, immediate-release fluvastatin 80mg/d and extended-release fluvastatin
80mg/d. Serum PCSK9 levels were measured at baseline and day 3 after treatment.
Results: Serum PCSK9 level was significantly higher on day 3 than that at baseline in all groups (all
p=0.0000). Moreover, after 3 days, serum PCSK9 level was significantly higher in immediaterelease
fluvastatin 80mg/d group than that in immediate-release fluvastatin 40mg/d group and
extended-release fluvastatin 80mg/d group (p=0.011, p=0.007, respectively), while no difference
was found between extended-release fluvastatin 80mg/d group and immediate-release fluvastatin
40mg/d group (p=1.000). However, data showed that there was no difference in lipid parameters
among groups on day 3.
Conclusion: The data firstly suggested that extended-release fluvastatin had lower impact on serum
PCSK9 levels and might be an alternative strategy for attenuating statin-induced elevation on PCSK9.