Abstract
On an annual basis, 13.2% of all deaths are attributable to coronary artery disease (CAD), which makes CAD - with 7.4 million deaths – the leading cause of death in the world. In this review, we discuss current knowledge in the pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation – myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, the ischemia-reperfusion injury, leftventricular remodeling and complications of MI. Furthermore, we add acute management strategies concentrating on medical therapy, a decision on the reperfusion strategy, timing and cardiac protection by ischemic preconditioning, post-conditioning and remote ischemic conditioning.
Keywords: Atherosclerosis, coronary artery disease, management, medical therapy, myocardial conditioning, myocardial infarction, pathophysiology.
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title:Pathophysiology of Myocardial Infarction and Acute Management Strategies
Volume: 14 Issue: 3
Author(s): Miha Tibaut, Dusan Mekis and Daniel Petrovic
Affiliation:
Keywords: Atherosclerosis, coronary artery disease, management, medical therapy, myocardial conditioning, myocardial infarction, pathophysiology.
Abstract: On an annual basis, 13.2% of all deaths are attributable to coronary artery disease (CAD), which makes CAD - with 7.4 million deaths – the leading cause of death in the world. In this review, we discuss current knowledge in the pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation – myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, the ischemia-reperfusion injury, leftventricular remodeling and complications of MI. Furthermore, we add acute management strategies concentrating on medical therapy, a decision on the reperfusion strategy, timing and cardiac protection by ischemic preconditioning, post-conditioning and remote ischemic conditioning.
Export Options
About this article
Cite this article as:
Tibaut Miha, Mekis Dusan and Petrovic Daniel, Pathophysiology of Myocardial Infarction and Acute Management Strategies, Cardiovascular & Hematological Agents in Medicinal Chemistry 2016; 14 (3) . https://dx.doi.org/10.2174/1871525714666161216100553
DOI https://dx.doi.org/10.2174/1871525714666161216100553 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Wide Pulse Pressure in the Elderly
Current Cardiology Reviews Hypertensive Heart Disease and the Role of Aldosterone Antagonists
Current Hypertension Reviews Changes in Serum Nampt Levels and Its Significances in Diabetic Nephropathy Patients-The Potential Role of Nampt in T2DM with Diabetic Nephropathy
Endocrine, Metabolic & Immune Disorders - Drug Targets A Review on Experimental Methods for Diabetes Induction and Therapeutic Efficacy of Anti-diabetic Drug Loaded Nanoformulation
Current Drug Therapy Biomarkers of Subclinical Atherosclerosis and Natural Products as Complementary Alternative Medicine
Current Pharmaceutical Design The State of the Problem of Achieving Extremely Low LDL Levels
Current Pharmaceutical Design Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances
Current Cardiology Reviews Imaging Reporters and Multimodal Molecular Bio-Imaging: A Database of Available Probes for Multi-Modality Bio-Imaging of Reporter Gene Expression
Recent Patents on Medical Imaging Circadian Cycle and Chronotherapeutics: Recent Trend for the Treatment of Various Biological Disorders
Recent Patents on Drug Delivery & Formulation Expression and Function of MicroRNAs in Heart Disease
Current Drug Targets Insulin Therapy for Improving Cardiac Surgical Outcomes
Current Drug Targets Current Therapeutic Concepts in Peripartum Cardiomyopathy
Current Pharmaceutical Design Season of Birth Effects on Reproduction in Women
Current Women`s Health Reviews Innate Immune Inflammatory Response in the Acutely Ischemic Myocardium
Medicinal Chemistry Cell Adhesion Molecules and Cadmium
Current Chemical Biology Genomic Variations Affecting Biological Effects of Statins
Current Drug Metabolism ACE2 and Diabetic Complications
Current Pharmaceutical Design Nutrition Communication in General Practice
Current Nutrition & Food Science The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a Marker Related to Diseased Conditions
Current Medicinal Chemistry Biochemical Markers of Cardiovascular Damage from Tobacco Smoke
Current Pharmaceutical Design