Background: According to the Indian traditional system of medicine, Paederia foetida L.
(Rubiaceae) is considered as the most valuable drug for numerous protective effects against different
types of metabolic diseases and disorders such as inflammation, arthritis, pain, etc. To date, no study
has been undertaken to scrutinize the systemic and topical anti-inflammatory effect of Paederia Foetida
L. The present study is an attempt to scrutinize systemic and topical anti-inflammatory effect of
Paederia foetida L and its possible mechanism of action.
Materials and Methods: In vitro antioxidant studies were performed via hydrogen peroxide (H2O2),
2,2-Diphenyl-1-picrylhydrazyl (DPPH), nitric acid (NO) and superoxide model for free radical scavenging
potential. Oral and topical anti-inflammatory activity of Paederia foetida L. methanolic extract
was experimented through carrageenan, egg albumin, serotonin, histamine, xylene, Arachidonic acid
(AA) and 12-O-tetradecanoylphorbol-acetate (TPA) established methods.
Result & Discussion: PF extract confirmed the presence of total phenolic phytoconstituents in the PF
extract. Invitro antioxidant studies confirmed that the PF extract scavenges the free radical in various
models. On the other hand, PF extract significantly reduces the carrageenan-induced inflammation by
inhibiting the synthesis of prostaglandin (PGE2); egg-induced inflammation via reduction in secretion
of serotonin and histamine. Topical inflammation induced by the xylene, TPA and AA, was subsided
significantly (P<0.001) by the PF extract in a dose-dependent manner via inhibition of PGE2, 5-
lipooxygenae and cyclo-oxygenase.
Conclusion: We can now conclude that PF extract inhibits the systemic and topical inflammation in dosedependent
manner. The PF extract probably inhibited the synthesis of PGE2, 5-lipooxygenae and cyclooxygenase.