Background: Diabetic nephropathy (DN) is one of the foremost causes of mortality in diabetic
patients as a result of increased urinary albumin excretion (UAE) rate and compromised renal
Introduction: Determination of increased excretion of albumin in urine chiefly attribute to the onset
and progression of DN. However, due to certain limitations of albuminuria, the search for more sensitive,
specific and reliable renal biomarkers is required for early prediction of DN.
Methods: Bibliographic investigation was made to scrutinize the data reporting relevant biomarkers
associated with DN and may be used to predict the onset and progression of nephropathy.
Result and Conclusion: Optimization of biomarkers for a clinical situation requires a prospective
validation in large numbers of patients with diabetic nephropathy and needs to be performed in different
critically ill populations.