Abstract
Background: Cancer medically, is a group of wide range of several diseases which are related with uncontrolled growth process of cells. A cross-sectional study was carried out to assess the concentration of cadmium (Cd), copper (Cu), lead (Pb) and zinc (Zn) in blood serum samples of cancer patients in comparison with healthy/control subjects.
Methods: A total of sixty subjects (30 cancer patients and 30 healthy subjects) were selected for this study from different hospitals of Karachi, Pakistan. Whole blood samples collected, digested and analyzed through graphite furnace atomic absorption spectrometry (GFAAS) for elemental analysis. Results: The results showed that the concentrations of these metals in blood serum of cancer patients were higher than healthy subjects. The mean concentration of Cd, Cu, Pb and Zn were 2.12, 1237.03, 1.87, 1084.74 µg/L respectively. The statistical data obtained was correlated to find the possible interaction between different metals. A negative correlation was observed between Pb/Zn (r = -0.521) in cancer and Cu/Zn (r= -0.431) in healthy individuals. Conclusion: The trend of metals in blood samples of cancer’s patients are as follows: Cu > Zn > Pb > Cd and in healthy individuals are: Zn > Cu > Pb > Cd. The statistical data reveals that there are significant differences found in between healthy and cancers individuals. Regular monitoring study should be carried out to create awareness on metal toxicity.Keywords: Blood, cancer patients, correlation, GFAAS, heavy metals, atomic absorption spectrometry.
Graphical Abstract
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Analytical methods for environmental and food analysis
In recent years, the study of the chemical composition of food and the environment depends on analytical methods in order to acquire information about the chemical composition, processing, quality control and contamination of soil, water, air, plants and foods, aspects very important for food safety and environmental quality control. There ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
Bioanalytical and Biosensor Technologies for Target Molecules
Bioanalytical and biosensor technologies constitute the core of detecting and sensing diverse molecules within living organisms, encompassing proteins, DNA, small molecular metabolites, and beyond. These molecules assume pivotal roles in biological processes, rendering their analysis and sensing indispensable for comprehending biological phenomena and unraveling disease mechanisms. In the current landscape ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Combinatorial Chemistry & High Throughput Screening
Current Medicinal Chemistry
The Natural Products Journal
Current Catalysis
Current Chinese Chemistry
Current Chinese Science
Current Topics in Chemistry
Related Books
Botanicals and Natural Bioactives: Prevention and Treatment of Diseases
Biosurfactants: A Boon to Healthcare, Agriculture & Environmental Sustainability
Frontiers in Computational Chemistry
Advances in Dye Degradation
Biological and Medical Significance of Chemical Elements
Frontiers In Medicinal Chemistry
Advances in Organic Synthesis
Frontiers in Natural Product Chemistry
Recent Advances in Analytical Techniques
Advanced Catalysts Based on Metal-organic Frameworks (Part 2)
34
1