It is well accepted that inflammatory bowel disease (IBD), including ulcerative colitis
and Crohn’s disease, is one of high risk factors for colorectal cancer (CRC). This supports
the notion that inflammation plays a key role in cancer development. Epidemiologic studies
have shown that vitamin D (Vit D) deficiency is associated with IBD and various types of
cancer including colorectal cancer. Clinical trials and mouse models have shown that Vit D is
beneficial in preventing or ameliorating inflammation and carcinogenesis. Mechanism studies
show that Vit D played wide-spectrum roles in anti-inflammation, immunoregulation, and
anti-cancer activities. In this review, we summarized and updated the findings on Vit D, IBD
and colitis-associated colorectal cancer (CAC) with the emphasis on the effects of Vit D on
anti-inflammation, EMT and cancer stem cells (CSC).
Keywords: Vitamin D, IBD, colitis-associated colorectal cancer, inflammation, NF-κ B, EMT, cancer stem cell.
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