Abstract
Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability.
Methods: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization. Results: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic features of nanoemulsion delivered via oral, intravenous, topical and nasal route. Conclusion: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits.Keywords: Hydrophobicity, oral delivery, pharmacokinetics, pharmacodynamics, routes of administration, carbon nanotubes.
Current Pharmaceutical Design
Title:Pharmacokinetic and Pharmacodynamic Features of Nanoemulsion Following Oral, Intravenous, Topical and Nasal Route
Volume: 23 Issue: 17
Author(s): Hira Choudhury*, Bapi Gorain, Bappaditya Chatterjee, Uttam K. Mandal, Pinaki Sengupta and Rakesh K. Tekade*
Affiliation:
- International Medical University, Department of Pharmaceutical Technology, Kuala Lumpur, 57000,Malaysia
- National Institute of Pharmaceutical Education and Research (NIPER) – Ahmedabad, Department of Pharmaceutics, Opposite Air Force Station Palaj-Basan Road, Gandhinagar, Gujarat 382355,India
Keywords: Hydrophobicity, oral delivery, pharmacokinetics, pharmacodynamics, routes of administration, carbon nanotubes.
Abstract: Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability.
Methods: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization. Results: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic features of nanoemulsion delivered via oral, intravenous, topical and nasal route. Conclusion: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits.Export Options
About this article
Cite this article as:
Choudhury Hira*, Gorain Bapi, Chatterjee Bappaditya, Mandal K. Uttam, Sengupta Pinaki and Tekade K. Rakesh*, Pharmacokinetic and Pharmacodynamic Features of Nanoemulsion Following Oral, Intravenous, Topical and Nasal Route, Current Pharmaceutical Design 2017; 23 (17) . https://dx.doi.org/10.2174/1381612822666161201143600
DOI https://dx.doi.org/10.2174/1381612822666161201143600 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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