Background: In this work, 2-[[5-(4-aminophenyl)-4-(4-substituted phenyl)-4H-1,2,4-
triazol-3-yl]thio]-1-(4-substituted phenyl)ethan-1-one derivatives (1-15) and 2-[[5-(4-aminophenyl)-
4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl]thio]-N-(4-substituted phenyl)acetamide derivatives
(15-30) were synthesized using 4-aminobenzohydrazide as starting material.
Methods: These compounds were screened to determine their antimicrobial activities against Grampositive
bacteria B. cereus, S. aureus, E. faecalis, L. monocytogenes; Gram-negative bacteria E. coli,
P. aeruginosa, K. pneumoniae, S. typhimurium, yeasts C. parapsilosis, C. albicans, C. glabrata, C.
krusei; molds A. niger, A. flavus, A. parasiticus, A. fumigatus, Rhizopus sp., A. alternate, S. rolfsii
and a mycobacteria M. tuberculosis.
Results and Conclusion: Compounds 2, 6, 7, 8 have displayed antituberculotic potential as much as
standard drug, rifampicin. Also, compounds have exhibited moderate antibacterial and antifungal
activities, contrary to expectations.