Abstract
Background: Caffeic acid (CA) and related phenylpropanoic acids are ubiquitous natural products of the shikimic acid pathway origin. Due to the presence of diorthohydroxyl aromatic (catecholic) moiety, CA is not only one of the most potent antioxidant phenyl propanoids but also displays numerous other pharmacological effects ranging from antiinflammatory to anticancer effects.
Objective: Recent studies also demonstrated that CA both in its free form or conjugated with other groups such as quinic acid and sugars displays profound effects in the brain including protection from toxicity induced by a variety of agents and/or experimental models of Alzheimer’s disease (AD). In this communication, the anti-AD therapeutic potential of CA and its two most common conjugated natural bioactive derivatives, chlorogenic acid (CGA) and caffeic acid phenethyl ester (CAPE), is scrutinised by reviewing literature in the past ten years. Besides the common global antioxidant effects, specific antiinflammatory mechanisms in the brain along with the various processes of β-amyloid formation, aggregation and neurotoxicity targets are discussed.
Conclusion: The mini-review also provides an insight into enhancing the therapeutic potential of existing anti-AD drugs by incorporating a CA structural moiety.
Keywords: Alzheimer's disease, beta-amyloid, caffeic acid phenethyl ester, caffeic acid, chlorogenic acid.
Mini-Reviews in Medicinal Chemistry
Title:Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update
Volume: 17 Issue: 8
Author(s): Solomon Habtemariam*
Affiliation:
- Pharmacognosy Research Laboratories & Herbal Analysis Services, Chatham-Maritime, Kent ME4 4TB,United Kingdom
Keywords: Alzheimer's disease, beta-amyloid, caffeic acid phenethyl ester, caffeic acid, chlorogenic acid.
Abstract: Background: Caffeic acid (CA) and related phenylpropanoic acids are ubiquitous natural products of the shikimic acid pathway origin. Due to the presence of diorthohydroxyl aromatic (catecholic) moiety, CA is not only one of the most potent antioxidant phenyl propanoids but also displays numerous other pharmacological effects ranging from antiinflammatory to anticancer effects.
Objective: Recent studies also demonstrated that CA both in its free form or conjugated with other groups such as quinic acid and sugars displays profound effects in the brain including protection from toxicity induced by a variety of agents and/or experimental models of Alzheimer’s disease (AD). In this communication, the anti-AD therapeutic potential of CA and its two most common conjugated natural bioactive derivatives, chlorogenic acid (CGA) and caffeic acid phenethyl ester (CAPE), is scrutinised by reviewing literature in the past ten years. Besides the common global antioxidant effects, specific antiinflammatory mechanisms in the brain along with the various processes of β-amyloid formation, aggregation and neurotoxicity targets are discussed.
Conclusion: The mini-review also provides an insight into enhancing the therapeutic potential of existing anti-AD drugs by incorporating a CA structural moiety.
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Cite this article as:
Habtemariam Solomon*, Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666161130100947
DOI https://dx.doi.org/10.2174/1389557516666161130100947 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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