Background: The genus Piper L. has the shikimic acid pathway predominantly expressed,
biosynthesizing many cinnamic acid derivatives (CAD).
Objective: Neolignans comprise an important class of CAD that exhibit a wide range of
pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant,
smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These
substances have been extracted and isolated from Piper species using different technics.
Results: The present review aims to summarize extraction and isolation methods and biological activities
of the different types of neolignans covering the period from 1968 to January 2016.