The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections

Author(s): J. Wang, X.-H. Liao, M. Zheng, D. Yang, X. Z. Zhou, H. Liu, K. P. Lu

Journal Name: Current Molecular Medicine

Volume 16 , Issue 9 , 2016

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Abstract:

Infection is the process of pathogen invasion, as well as the host reaction to the foreign agents. Proline-directed phosphorylation is a major regulatory mechanism that regulates the function of fundamental proteins involved in infection and infection-induced cancer. Recently, the identification of the phosphorylation-dependent prolyl isomerase Pin1 has uncovered a unique regulatory signaling mechanism controlling protein conformation and function after phosphorylation. Pin1 is the only proline isomerase that specifically recognizes certain Pro-directed Ser/Thr phosphorylation motifs. Pin1 has emerged as a major regulator of cancerrelated viral and bacterial infections notably via activating Toll-like receptor signaling and NF-κB pathways. This paper will specifically review recent findings on the role of Pin1 in cancer-related viral and bacterial infections and also discuss newly discovered Pin1 inhibitors as promising drugs for the prevention and treatment of viral and bacterial infections and associated tumorigenesis.

Keywords: Prolyl isomerase Pin1, cancer-related viral and bacterial infections, ATRA, inflammatory response, NF- κB, Toll-like receptors.

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2016
Page: [793 - 802]
Pages: 10
DOI: 10.2174/1566524016666161124103654
Price: $65

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