Novel Chromeno[2,3-d]pyrimidines-Design, Synthesis and Antioxidant Activity

Author(s): Kotiah Yalagala, Sreekantha B. Jonnalagadda*, Suresh Maddila, Surjyakanta Rana, Surya Narayana Maddila

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 7 , 2017

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Graphical Abstract:


Introduction: Fourteen novel 8,8-dimethyl-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)- one derivatives were rationally designed and synthesized successfully. The synthetic procedures adopted for the target molecules were achieved by facile protocols and the yields were good to excellent (> 80%).

Method: All the synthesized compounds were characterized by 1H NMR, 13C NMR, HR-MS and FT-IR spectral analysis. All new compounds were evaluated for their in vitro antioxidant activity by using DPPH, ABTS, NO and H2O2 methods.

Results: Among the novel derivatives, two of the synthesized compounds exhibited good antioxidant activities similar to ascorbic acid, in all the four tested methods.

Keywords: Pyrimidines, synthesis, anti-oxidant activity, simple method, in vitro studies, human body.

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Article Details

Year: 2017
Page: [763 - 772]
Pages: 10
DOI: 10.2174/1570180814666161123143637
Price: $65

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