Title:Emerging Nanocarriers-based Approaches to Diagnose and Red uce Vascular Inflammation in Atherosclerosis
VOLUME: 24 ISSUE: 6
Author(s):Manuela Calin and Ileana Manduteanu
Affiliation:Institute of Cellular Biology and Pathology "Nicolae Simionescu", 8, BP Hasdeu Street, P.O. Box 35-14,050568-Bucharest
Keywords:Atherosclerosis, diagnosis, inflammation, nanoparticles, nanotherapy, vascular wall.
Abstract:Exploitation of nanotechnology advances in the cardiovascular medicine has led to
new approaches for the diagnosis and therapy of vascular inflammation associated to cardiovascular
diseases. Innovative nanoparticles targeted to the main players in the arterial wall
inflammation in atherosclerosis (i.e. inflammatory molecules, immune or resident cells) have
been already developed to diagnose and/or reduce excessive vascular inflammation and is eagerly
awaited that promising preclinical and early clinical results to boost the approval of the
first nanocarrier in this field. This review discusses the challenges and the steps undertaken so
far to produce powerful multifunctional nanoparticles capable of raising new scenarios for
future precision medicine in atherosclerosis.
