Self-assembly of DNA-based Nanomaterials and Potential Application in Drug Delivery

Author(s): Zhiyong Zhao, Feng Liang, Simin Liu*

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 16 , 2017


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Abstract:

DNA can be self-assembled into programmable two-dimensional and three-dimensional nanoarchitectures with arbitrarily predetermined sizes and shapes. Because of the addressable arbitrary size and shape, great capacity of cargo loading, ability to be internalized by cells, the stability of structures under physiological conditions and excellent biocompatibility, the pristine DNA nanostructures are explored as drug vehicles in drug delivery. In addition, DNA block copolymer and DNADendron hybrid, as new building blocks, can be self-assembled into different kinds of ordered structures, e.g., nanofibers, spherical micelles, and vesicles, in aqueous solution. Recent studies have shown that some of these nanostructures could easily enter cells with excellent cell uptake efficiency. Herein, this review will mainly introduce the self-assembly behavior of pristine DNA and DNA hybrid materials including DNA block copolymers and DNA-Dendron hybrids, and their application in drug delivery.

Keywords: DNA block copolymer, DNA-Dendron hybrid, Self-assembly, Nanomaterial, Drug delivery.

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Article Details

VOLUME: 17
ISSUE: 16
Year: 2017
Published on: 28 April, 2017
Page: [1829 - 1842]
Pages: 14
DOI: 10.2174/1568026617666161122121142
Price: $65

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