Background: Amnestic MCI (aMCI) has notably increased in Shanghai, China.
Objective: The study was designed to estimate the prevalence and incidence rates of aMCI and to determine
the risk and protective factors for aMCI among persons ≥ 60 years-old and ≥ 70 years-old in Shanghai communities,
Method: We carried out this 1-year longitudinal study to survey a random sample of 1,302 individuals ≥ 60
years-old, to collect baseline and follow-up data about lifestyle through self-reports, and vascular and comorbid
conditions from medical records and a physical examination. We also analyzed a subgroup of individuals ≥
Results: The prevalence rate of aMCI in persons ≥ 60 years-old was 22.3%, and the incidence rate (per 1,000
person-years) was 96.9. Being female was a risk factor for aMCI; protective factors included smoking, drinking
tea, engaging in intellectual work before retirement, social activities and hobbies, regular reading habits,
and surfing the internet. The prevalence rate of aMCI in persons ≥ 70 years was 30.3%, and the incidence rate
was 145.6. Smoking, drinking tea, and surfing the internet were not protective factors for this age group (≥ 70
Conclusion: The present study indicates that aMCI is a considerable health problem in Shanghai. Preventive
strategies for aMCI are needed to enhance lifestyle factors that promote brain activity.