Structure and Intramolecular Dynamics of Biologically Active Compounds: Analysis of NMR Spectra Transformed by Spin Labels
Pp. 159-218 (60)
Vladimir K. Voronov and Igor A. Ushakov
The present review summarizes current applications of the NMR
phenomenon in paramagnetic systems for studying structure and intramolecular
dynamics of multielectron molecular systems. The potential of spin labels for
molecular identification was demonstrated in the example of structural biology issues.
Discussion of molecular structure of specific organic heteroatomic compounds and
their complexes is preceded by the section, where peculiarities of the NMR phenomenon
in paramagnetic systems are considered. In opinion of the authors of the review,
such consideration is needed for researchers who are not experts in the NMR theory.
The separate section of the review is devoted to a method for investigation of structure
and dynamics of complex molecular systems. This method is based on application of
the NMR spectra transformed by complexes, first of all, paramagnetic ones (spin
Hyperfine coupling, Method of paramagnetic additives, Nuclear
magnetic resonance, Paramagnetic systems, Structure and dynamics of molecules.
Irkutsk State Technical University, Irkutsk, Russia.