Polyphenolic Compound from Vitis vinifera L. have Potential for the Alzheimer Disease Treatment

Title:Polyphenolic Compound from Vitis vinifera L. have Potential for the Alzheimer Disease Treatment

Volume: 14 Issue: 7

Author(s): Soukup Ondrej, Stralkova Radomira, Mistova Tereza, Popov Marek, Hejtmankova Alena, Lachman Jaromir, Klimova Blanka and Kuca Kamil*

Affiliation:

• Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove,Czech Republic

Keywords: Alzheimer's disease, grape wine extract, prolyl oligopeptidase, oxidative stress, catechins, polyphenols.

Abstract: Background: Grape marc and the wine cakes are known for high content of catechins, which have been reported to have many beneficial effects for human health. The most important are the effects on cardiovascular system. Also some potential to combat the Alzheimer´s disease has been reported for catechins contained in a green or white tea.

Objective: To extract polyphenols from the wine grape seeds and try to characterize basic targets, which play an important role in AD.

Methods: Using HPLC method we have identified and assessed the content of various catechins in the wine cake and grape seeds extracts. Applying in vitro methodologies we have evaluated the potency of the extract to inhibit acetylcholinesterase and prolyl oligoesterase. We also assessed the effect on the cell viability (MTT test) and its antioxidant activity (DPPH test)

Results and Conclusion: It was shown that Pinot Gris, Pinot Noir and Hibernal are the varieties containing most of the polyphenolic compounds. Catechin followed by epicatechin and epigallocatechin were the most abundant polyphenols in the cake extract. We also report the biological activity of the extract with regard to a potential to improve cognitive decline associated with neurodegenerative disease like the Alzheimer´s disease. Apart from the expected antioxidant activity, there is an interesting prolyl oligopeptidase affinity, which can be an added value for targeting the cognitive decline.

Cite this article as:

Ondrej Soukup, Radomira Stralkova, Tereza Mistova, Marek Popov, Alena Hejtmankova, Jaromir Lachman, Blanka Klimova and Kamil Kuca*, Polyphenolic Compound from Vitis vinifera L. have Potential for the Alzheimer Disease Treatment, Letters in Drug Design & Discovery 2017; 14 (7) . https://dx.doi.org/10.2174/1570180814666161116112300

DOI https://dx.doi.org/10.2174/1570180814666161116112300	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X