Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones

Author(s): Sunetra Jadhav, Ajinkya Patravale, Reshma Patil, Digambar Kumbhar, Vishram Karande, Dattatray Chandam, Madhukar Deshmukh*

Journal Name: Current Green Chemistry

Volume 3 , Issue 3 , 2016

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Background: A straightforward protocol for the one-pot synthesis of a series of novel thiazolopyrimidine derivatives has been developed.

Method: In which multicomponent reaction between thiobarbituric acid, 2-aminothiozole and several substituted aldehydes using sulfamic acid (20 mol%) as a heterogeneous and easily recoverable catalyst in ethanol under reflux condition.

Conclusion: This method has several advantages like greener synthetic approach, good to excellent yield (82-91%), cost-effectiveness, easy work-up and atom-economic procedure.

Keywords: 2-Aminothiazole, 2-thiobarbituric acid, thiazolopyrimidine derivatives, sulfamic acid, atom economy, multicomponent reaction.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Published on: 27 April, 2017
Page: [227 - 234]
Pages: 8
DOI: 10.2174/2213346103666161115124757
Price: $25

Article Metrics

PDF: 21