Abstract
The survival of children with cancer has improved dramatically in the last decades. Survivors of childhood cancer are at increased risk of long-term complications of therapeutic exposure. Second malignant neoplasms are one of the most severe side effects of cancer treatment. The frequency and type of secondary cancers may vary depending on the initial diagnosis, treatment administered and genetic predisposition. This review highlights the risk factors in the development of SMNs in survivors of pediatric cancers and their differences according to primary cancer type, genetic predisposition and treatment admistered. Finally, the review emphasizes the need for life-time follow-up of survivors of childhood cancer for the development of second malignancies.
Keywords: Cancer, children, chemotherapy, radiotherapy, secondary malignant neoplasms.
Current Pediatric Reviews
Title:Secondary Neoplasms in Children Treated for Cancer
Volume: 13 Issue: 1
Author(s): Rejin Kebudi*Gul Nihal Ozdemir
Affiliation:
- Istanbul University, Cerrahpasa Medical Faculty & Oncology Institute, Pediatric Hematology- Oncology Dept., Istanbul,Turkey
Keywords: Cancer, children, chemotherapy, radiotherapy, secondary malignant neoplasms.
Abstract: The survival of children with cancer has improved dramatically in the last decades. Survivors of childhood cancer are at increased risk of long-term complications of therapeutic exposure. Second malignant neoplasms are one of the most severe side effects of cancer treatment. The frequency and type of secondary cancers may vary depending on the initial diagnosis, treatment administered and genetic predisposition. This review highlights the risk factors in the development of SMNs in survivors of pediatric cancers and their differences according to primary cancer type, genetic predisposition and treatment admistered. Finally, the review emphasizes the need for life-time follow-up of survivors of childhood cancer for the development of second malignancies.
Export Options
About this article
Cite this article as:
Kebudi Rejin*, Ozdemir Nihal Gul, Secondary Neoplasms in Children Treated for Cancer, Current Pediatric Reviews 2017; 13 (1) . https://dx.doi.org/10.2174/1573396313666161114233135
DOI https://dx.doi.org/10.2174/1573396313666161114233135 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Characterization of the Immune Inflammatory Profile in Obese Asthmatic Children
Endocrine, Metabolic & Immune Disorders - Drug Targets Reduction of Doxorubicin-Induced Cardiotoxicity Using Nanocarriers: A Review
Current Drug Metabolism Frontal Lobe Synaptic Plasticity in Development and Disease: Modulation by the Dopamine D1 Receptor
Current Pharmaceutical Design Histopathology, Immunohistochemistry and Molecular Biology of Follicular Epithelium-Derived Pediatric Thyroid Carcinomas
Current Pediatric Reviews The use of nanocarriers in acute myeloid leukaemia therapy: challenges and current status.
Current Pharmaceutical Biotechnology A Scientific Approach to Anti-Ageing Therapies: State of the Art
Current Pharmaceutical Design The Treatment of Cardiovascular Disease Continuum: Focus on Pharmacologic Management and RAS Blockade
Current Clinical Pharmacology KRAS Mutation Testing of Colorectal Cancer for Anti-EGFR Therapy: Dogmas Versus Evidence
Current Cancer Drug Targets The Redox Biology of Schistosome Parasites and Applications for Drug Development
Current Pharmaceutical Design High Dose Immunoglobulin (IVIG) May Reduce the Incidence of Langerhans Cell Histiocytosis (LCH)-Associated Central Nervous System Involvement
CNS & Neurological Disorders - Drug Targets Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population
Current Neuropharmacology Epigenetics and Adult Acute Myeloid Leukemia
Current Pharmacogenomics and Personalized Medicine Maternal Fish Oil Supplementation: The Prodrom of Synaptic Protection in Alzheimers Disease
Current Nutrition & Food Science Signal Transduction of Steroidogenic Hormones to the Adrenal and Gonadal Mitochondria and the Possibilities for Combating Lipoid Congenital Adrenal Hyperplasia
Current Signal Transduction Therapy Nitric Oxide: Cancer Target or Anticancer Agent?
Current Cancer Drug Targets Non Alcoholic Fatty Liver: Epidemiology and Natural History
Reviews on Recent Clinical Trials Viral Encephalitis: Current Treatments and Future Perspectives
Central Nervous System Agents in Medicinal Chemistry Biochemical Markers of Autoimmune Diseases of the Nervous System
Current Pharmaceutical Design Gene Therapy for Chronic Granulomatous Disease: Current Status and Future Perspectives
Current Gene Therapy Recurrent Left Atrial Low-grade Malignant Inflammatory Myofibroblastic Tumor Characterized by Cardiovascular Magnetic Resonance
Current Medical Imaging