Background: The sestrin family includes several conserved stress-induced proteins that contribute
to the maintenance of homeostasis, DNA stability and cell viability in response to various types
Objective: It is well established that the protective functions of AMP-dependent protein kinase
(AMPK) and/or mammalian target of rapamycin (mTOR) are regulated by sestrins. Additionally, it has
been revealed that sestrins are able to protect cells from oxidative stress by scavenging reactive oxygen
Method: The essential involvement of sestrins in mTORC1 inhibition and ROS scavenging signaling
pathways, which modulate metabolism homeostasis and regulate autophagy, indicates that sestrins may
serve as a potential agent for cell growth, development, metabolism, and neurodegenerative disorders.
However, the potential role of sestrins in stroke has not been discussed and summarized.
Results & Conclusion: Based on the current understanding of sestrins, it is believed that sestrins are one
of the potential endogenous protective molecules/mechanisms following cerebral stroke, which are associated
with neuronal protection, neuroinflammation suppression, and blood brain barrier preservation.