Background: Resveratrol belonging to stilbene family has emerged as a leading candidate for
enhancing the health span by potentially decreasing the aging process and reducing chronic diseases.
Objective: The aim of this review is to focus on various studies related to chemical composition l,
pharmacological activities, bioavailability problems associated with resveratrol. In addition, it includes
section discussing the challenges associated with drug and strategies to improve resveratrol solubility,
stability and bioavailability.
Current Scenario: It is being revealed currently in various literature that resveratrol is a potential drug
candidate with multi-spectrum pharmacological applications. The poor bioavailability of resveratrol in
humans is a matter of great concern for transforming basic science findings into clinical application. Although
couple of research projects have emerged from human clinical trials, however results are conflicting,
that may partially belong to defined dosing protocols. A number of theoretical methods have
been developed to improve the bioavailability of resveratrol, including micronization of particles which
are combined with additional phytochemicals, novel delivery systems, and nanotechnology applied
Conclusion: If bioavailability is such a limitation in the clinical application of resveratrol, then methods
need to be optimized for resveratrol formulations. Drug stability needs to be improved, so that the
bioavailability enhances and side-effects of resveratrol reduces. The novel drug delivery systems have
been designed to bring this potential molecule to the first line treatment of diseases. This review focuses
on the current bioavailability literature, reveals data from humans, and provides suggested actions to be
taken for future research.