Background: Oxidative stress and amyloid deposition are tightly interconnected pathological
features of Alzheimer disease. In this respect, both amyloid production and aggregation may be stimulated
by oxidative stress and also the increase of pathogenic β-amyloid and its aggregated form lead to
oxidative stress progression. Therefore, the search for potential drugs with both antioxidant and antiaggregation
properties are of great interest.
Methods: In this study, we described the stereospecific synthesis of alkaloid securinine aminoderivatives.
Results: We showed that the newly synthesized compounds possess antioxidant and metal-chelating
properties. Indeed, we report that one compound has inhibitory effects towards μ-amyloid aggregation.
Conclusion: Based on these results, aminoderivatives of securinine scaffold are promising compounds
for development of new drugs for the treatment of neurodegenerative diseases.