Metastatic Cancer Stem Cell Niche and the Tolllike Receptor 4 (TLR4)-mediated Premetastatic Microenvironment
Pp. 74-108 (35)
Takeshi Tomita, Atsuko Deguchi and Yoshiro Maru
Cancer metastasis is one of the most crucial problems in the field of medical
research. There are two types of approaches to find a new way to treat cancer
metastasis; Targeting cancer stem cells, or stromal cells in the premetastatic phase.
Interactions between these two elements synergistically enhance the survival of
metastatic cancer cells and promote their re-growth in the distant organ. In this review,
first we summarize the recent trends in cancer stem cell studies. Then, we discuss the
premetastatic phase, based on our investigations. We also review various types of
tumor-associated stromal cells (monocyte/macrophage, fibroblast, adipocyte, dendritic
cell, neutrophil, and natural killer cell) in relations with the tumor microenvironment
formation. Moreover, dormant tumor cells and circulating tumor cells are included in
Biglycan, CCL2, CCR2, Circulating tumor cell, Dormant cell, EMT,
Eph, Ephrin A1, HMGB1, Inflammation, MD-2, Metalloprotease, Organ tropism,
Premetastatic microenvironment, S100A8, SAA3, TGF-β, TLR4, TNFα, VEGF.
Department of Pharmacology, Tokyo Women’s Medical University, 8-1 Kawada, Shinjuku, Tokyo, 162-8666, Japan.