Title:A Review on Advances in Organoborane-Chemistry: Versatile Tool in Asymmetric Synthesis
VOLUME: 14 ISSUE: 5
Author(s):Paranjeet Kaur, Gopal L. Khatik* and Surendra Kumar Nayak
Affiliation:Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara (Punjab) 144411, Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar- Delhi G.T. Road (NH-1), Phagwara (Punjab), 144411, Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara (Punjab) 144411
Keywords:Asymmetric synthesis, chirality, borylation, organoborane, hydroboration.
Abstract:Background: In the past decades, the hydroboration reaction was serendipitously discovered which
occurred by the facile addition of diborane to alkenes and alkynes. Hydroboration reactions produce organoboranes.
The organoboranes have marked a new era in the field of organic chemistry because they are versatile
chemical intermediates that are readily available to chemists.
Objective: The review focuses on recent advancements in organoborane reagents in asymmetric synthesis. We
searched the scientific database using relevant keywords such an asymmetric hydroboration, organoboranes
etc. The quality research papers were included in the review which discusses the asymmetric synthesis via organoborane
compounds.
Conclusion: The development of organoborane compounds increased remarkably in few years after hydroboration
reaction discovered. Later on, new selective hydroboration agents were developed (for example thexylborane,
disiamylborane, dipinylborane, 9-borabicyclenonane, and diisopinocamphylborane which have proven
valuable in syntheses of organic compounds with new carbon-carbon bonds. H.C Brown and his co-workers
established various procedures to synthesize asymmetric compounds with high enantiomeric excess (ee). There
are many different types of strategies in the asymmetric syntheses, but asymmetric syntheses via chiral organoborane
reagents have proven to be truly general and have been used to achieve reactions resulting in excellent
ee. This review focuses on the advancement.
