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eISBN: 978-1-68108-347-6, 2016 ISBN: 978-1-68108-348-3
Indexed in: Book Citation Index, Science; BIOSIS Previews
A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches.
Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells I the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis.
This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.
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Division of Hematology and Oncology Department of Medicine Department of Otolaryngology Department of Oncological Sciences Tisch Cancer Institute at Mount Sinai Ichan School of Medicine at Mount Sinai New York, United States