Flow Biocatalytic Processes in Ionic Liquids and Supercritical Fluids

Author(s): Pedro Lozano, Susana Nieto, Jose L. Serrano, Jose Perez, Gregorio Sanchez-Gomez, Eduardo García-Verdugo, Santiago V. Luis

Journal Name: Mini-Reviews in Organic Chemistry

Volume 14 , Issue 1 , 2017

Become EABM
Become Reviewer

Graphical Abstract:


The use of ionic liquids (ILs) and supercritical fluids (SCFs), as alternative non-aqueous reaction media for carrying out selective biocatalytic transformations, has substantially increased the opportunities for developing clean and sustainable chemical processes with industrial interest, which were enhanced by combination with continuous flow systems. The excellent suitability of ILs to over-stabilize enzymes, combined with the excellences of supercritical carbon dioxide (scCO2) to dissolve and transport chemicals, provides useful synergies for designing continuous clean synthetic approaches, that directly provide pure products by using appropriate reactor (e.g. membrane reactors). Several examples (i.e. DKR of sec-alcohols, synthesis of biodiesel, etc.), where the use of continuous flow techniques with multi-catalytic synthesis are combined into a single continuous operation, are provided in this paper.

Keywords: Sustainable chemistry, applied biocatalysis, ionic liquids, supercritical fluids, flow reactors, organic synthesis, flavors, biodiesel.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2017
Page: [65 - 74]
Pages: 10
DOI: 10.2174/1570193X13666161103145723
Price: $65

Article Metrics

PDF: 20