Opioids Resistance in Chronic Pain Management

Author(s): Luigi A. Morrone, Damiana Scuteri, Laura Rombola, Hirokazu Mizoguchi, Giacinto Bagetta

Journal Name: Current Neuropharmacology

Volume 15 , Issue 3 , 2017

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Graphical Abstract:


Chronic pain management represents a serious healthcare problem worldwide. Chronic pain affects approximately 20% of the adult European population and is more frequent in women and older people. Unfortunately, its management in the community remains generally unsatisfactory and rarely under the control of currently available analgesics. Opioids have been used as analgesics for a long history and are among the most used drugs; however, while there is no debate over their short term use for pain management, limited evidence supports their efficacy of long-term treatment for chronic noncancer pain. Therapy with opioids is hampered by inter-individual variability and serious side effects and some opioids often result ineffective in the treatment of chronic pain and their use is controversial. Accordingly, for a better control of chronic pain a deeper knowledge of the molecular mechanisms underlying resistance to opiates is mandatory.

Keywords: Chronic pain, opiate resistance, polymorphisms.

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Article Details

Year: 2017
Page: [444 - 456]
Pages: 13
DOI: 10.2174/1570159X14666161101092822
Price: $65

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