Objective: The present review article presented a detailed account of the design strategies
and the structure activity relationship of different derivatives apart from the nitrogen containing ring.
These scaffolds play an important part in the drug discovery which showed anticancer activity against
different human cancer cell lines through apoptosis, cell cycle arrest, inhibiting kinases, angiogenesis,
disruption of cell migration, modulation of nuclear receptor responsiveness and others. Naphthalenes
amides/amidines, furan, podophyllotoxin, platinum compounds, steroids, and urea, which forms the
core part or along with other N-heterocyclic rings are enclosed. Some of these compounds e.g. podophyllotoxin
and platinum based drugs displayed anticancer activity at nanomolar range. Various substitutions
from the earlier and latest information are prerequisite in the drug synthesis process.
Conclusion: The review focused on the recent development of these derivatives, design and anticancer
properties, thus providing with the most profound knowledge for the development of targeted based