Oxidative stress in brain underlies the major neurological disorders including Alzheimer’s
disease (AD) and Parkinson’s disease (PD). Peripherally, Angiotensin-II is a major effector of
inflammation. Identification of its capacity to access brain during hypertension, as well as location of
central renin angiotensin system have led to its recognition as the major effector of oxidative stress in
brain. Clinical uses of antioxidants to antagonize this oxidative stress have mostly failed. In this
scenario, AT1 blockers have been investigated to prevent neurodegeneration. Although it has shown
promise, clinical efficacy is limited to few drugs including telmisartan mainly due to the poor brain
availability of others. In this review we aim to analyze the potential of antioxidants to reduce oxidative
stress in brain. We have given critical analysis of the approaches for re-purposing of AT1 blockers
against oxidative stress induced neurodegeneration.
Keywords: Angiotensin, antioxidant, neuroprotection, oxidative stress.
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