Background: On the basis that various substituted salicylamides have shown interesting
biological properties, we designed and synthesized new salicylamide derivatives with dipeptide
Methods: The synthesis was based on the gradual building of target molecules and provided
optically pure compounds.
Conclusion: The obtained compounds were tested for their antiproliferative effect against three
leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.
Keywords: Salicylamides, antiproliferative activity, cytotoxic activity, pharmacological activity, amines.
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