Peculiarities of the Clinical Course of Oxidative Protein and Lipid Modification in Children with Acute Rheumatic Fever

Author(s): Bibigul Tukbekova, Sandugash Dyussenova, Saule Kizatova, Tattigul Kenzhetayeva, Karlygash Zhubanysheva, Kulziya Zhaktayeva, Saida Sadvakassova, Gulmira Serikova, Nazym Yerimbetova, Aiman Issayeva

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 16 , Issue 4 , 2016

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Background: Measuring indicators of oxidative protein and lipid metabolism is a diagnostic criterion of oxidative metabolism disruption at the early stages of chronic somatic pathology formation. Purpose was to assess the status of protein and lipid oxidative metabolism as a pathogenic link of acute rheumatic fever by measuring markers of early lesion.

Methods: Research included measurement of lipid peroxidation products and efficiency of antioxidant protection.

Results: It revealed unidirectional changes that confirm significant cellular membrane lesion. Determined changes correlated with the activity level of the pathological process while comparing the indicators of ill children in remission and during exacerbation. It was found that despite the active traditional treatment in hospitals for in-patients, a number of studied indicators did not return to normal in remission. This shows the persistence of membrane destruction processes in the body, which supports the pathological process and requires an investigation of the lesion severity at the level of cell metabolism.

Conclusion: Determination of disruption in the oxidative metabolism system of lipids and proteins, and the presence of mitochondrial insufficiency signs are universal pathogenic mechanism that reflects the multifactorial nature of the lesion with acute rheumatic fever.

Keywords: Antioxidant, children, lipid peroxidation, pediatrics, protein modification.

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Article Details

Year: 2016
Page: [254 - 263]
Pages: 10
DOI: 10.2174/1871530316666161019161433
Price: $65

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