Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of
novel indole-isoxazole hybrids.
Method: The synthetic procedure was started from different ethyl 5-arylisoxazole-3-carboxylate
derivatives. Hydrolysis and reaction of the later compound with tryptamine afforded the desired
products in good yields.
Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl)
isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity.
Keywords: Acetylcholinesterase, Alzheimer’s disease, Butyrylcholinesterase, Heterocycles, Indole, Isoxazole.
Rights & PermissionsPrintExport