Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-Cholinesterase Activity

Author(s): Fahimeh Vafadarnejad, Mina Saeedi, Mohammad Mahdavi, Ali Rafinejad, Elahe Karimpour-Razkenari, Bilqees Sameem, Mahnaz Khanavi, Tahmineh Akbarzadeh*

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 6 , 2017

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Graphical Abstract:


Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids.

Method: The synthetic procedure was started from different ethyl 5-arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction of the later compound with tryptamine afforded the desired products in good yields.

Conclusion: Among the synthesized compounds, N-(2-(1H-indol-3-yl)ethyl)-5-(2-chlorophenyl) isoxazole-3-carboxamide (4b) showed the best anti-cholinesterase activity.

Keywords: Acetylcholinesterase, Alzheimer’s disease, Butyrylcholinesterase, Heterocycles, Indole, Isoxazole.

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Article Details

Year: 2017
Published on: 06 June, 2017
Page: [712 - 717]
Pages: 6
DOI: 10.2174/1570180813666161018124726
Price: $65

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