Title:Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review
VOLUME: 17 ISSUE: 4
Author(s):Vinit Raj, Amit Rai and Sudipta Saha*
Affiliation:Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Rai Bareli Road, Lucknow-226025
Keywords:1, 3, 4-thiadiazole, cancer cell lines, structure-activity-relationship, mechanism of action.
Abstract:The chemistry of heterocyclic containing, 1,3,4-thiadiazole has been an interesting field of study from
ancient years. Subsequently, 1,3,4-thiadiazole nucleus constitutes a significant class of compounds for new drug
development. Recently, various 1,3,4-thiadiazole derivatives synthesized and evaluated their biological activities
including antimicrobial, antituberculosis, antioxidant, anti-inflammatory, anticonvulsants, antidepressant and
anxiolytic, antihypertensive, anticancer and antifungal activity. The search for anticancer compounds with more
selective activities and lower side effect continues to be an active area of argument examination in medicinal
chemistry. This review elaborately described the medicinal chemistry, their structural activity relationship, and
anticancer properties with respect to human cell line based approach related to synthesized 1,3,4-thiadiazole
derivatives.
