Nanotechnology has provided powerful tools to improve the chemotherapy of cancer.
Different nanostructures have been developed which deliver the anticancer drugs more selectively to
tumor than to healthy tissues. The result has generally been the increase in efficacy and safety of
classical anticancer drugs. In recent years, several studies have focused not only on the delivery of
anticancer drugs to tumors, but also on delivering the drugs to specific organelles of cancer cells.
Endoplasmic reticulum, Golgi apparatus, lysosomes, mitochondria, and nucleus have been the targets of
different nanostructured drug delivery systems developed with the goal of circumventing drugresistance,
increasing drug efficacy, and so on. So far, the results described in the literature show that
this strategy may be used to improve chemotherapy outcomes. In this review a discussion is presented
on the strategies described in the literature to deliver anticancer drugs to specific organelles of cancer
cells by using nanostructures.
Keywords: Anticancer therapy, chemotherapy, nanostructured drug delivery systems, nanotechnology, subcellular delivery.
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