The therapy of various diseases by the drugs entrapped in calixarene derivatives is gaining attraction of
researchers nowadays. Calixarenes are macrocyclic nano-baskets which belong to cavitands class of host-guest
chemistry. They are the marvelous hosts with distinct hydrophobic three dimensional cavities to entrap and encapsulate
biologically active guest drugs. Calixarene and its derivatives develop inclusion complexes with various
types of drugs and vitamins for their sustained/targeted release. Calixarene and its derivatives are used as carriers
for anti-cancer, anti-convulsant, anti-hypertensive, anthelmentic, anti-inflammatory, antimicrobial and antipsychotic
drugs. They are the important biocompatible receptors to improve solubility, chemical reactivity and
decrease cytotoxicity of poorly soluble drugs in supramolecular chemistry. This review focuses on the calixarene
and its derivatives as the state-of-the-art in host-guest interactions for important drugs. We have also critically
evaluated calixarenes for the development of prodrugs.
Keywords: Calixarene, supramolecular, medicinal uses, drug release, prodrugs, drug design.
Rights & PermissionsPrintExport