Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores
covalently linked in a single molecule. In the field of anti-infective agents, they have been
proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity
and less probability of eliciting high level resistance linked to single gene product. Although less
frequently explored, they could also be useful in the treatment of frequently occurring co-infections.
Here, we overview recent advances in the field of hybrid antimicrobials. Furthermore, we discuss some
cutting-edge approaches to face the development of designed multi-target agents in the era of omics and
big data, namely analysis of gene signatures and multitask QSAR models.
Keywords: Hybrid drug, Hybrid molecule, Chimeric molecule, Anti-infective, Antimicrobial, Antibiotic, Antifungal, Antiviral,
Antimicrobial resistance, Multi-target drug, Multi-target agents.
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