Hybrid drug strategy is based on the combination of two or more pharmacophores into a
new chemical entity to improve the properties of the original compounds or to obtain double action of
resulting molecule. Hybrid molecules, comprised of some pharmacophore and nitric oxide (NO) donor
moiety, constitute one of the more promising approaches for the design of drugs. Furoxans and
benzofuroxans are considered NO releasing prodrugs and are of great interest for researchers. In this
review we will focus on furoxan and benzofuroxan hybrids described in literature during the last
years (from 2005 to 2016).
Keywords: Furoxan, Benzofuroxan, NO-donor, Hybrid, Pharmacophore.
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