Long Non-Coding RNA: An Emerging Paradigm of Pancreatic Cancer

Author(s): T. Han, H. Hu, M. Zhuo, L. Wang, J.-J. Cui, F. Jiao, L.-W. Wang

Journal Name: Current Molecular Medicine

Volume 16 , Issue 8 , 2016

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Abstract:

Pancreatic cancer remains a worldwide issue and burden that is hard to resolve given its low resection rate and chemo-resistance. Early diagnosis and early treatment are critical for conquering pancreatic cancer. Therefore, new biomarkers for diagnosis and prognosis are urgently needed. Previously, researchers mainly focused on protein-coding genetic and epigenetic changes in many types of cancers, and regarded the noncoding part as waste. Recently, however, long non-coding RNA (lncRNA) has emerged as a major participant in carcinogenesis, as it regulates cell proliferation, migration, invasion, metastasis, chemo-resistance, etc. The underlying mechanisms are summarized as signaling, decoy, guide and scaffold, yet the specific regulation networks remain to be uncovered. Several studies have revealed that some lncRNAs are dysregulated in pancreatic cancer, participating in biological functions. In this review, we will briefly outline the functional lncRNAs in pancreatic cancer, decipher possible mechanisms of lncRNAs, and further explore their significance in pancreatic cancer.

Keywords: Long non-coding RNA, pancreatic cancer, biomarkers, carcinogenesis, treatment, targets.

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2016
Published on: 06 November, 2016
Page: [702 - 709]
Pages: 8
DOI: 10.2174/1566524016666160927095812
Price: $65

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