Title:Targeted Therapy Towards Cancer-A Perspective
VOLUME: 17 ISSUE: 3
Author(s):Sean L. Kitson, Vincenzo Cuccurullo, Andrea Ciarmiello and Luigi Mansi
Affiliation:Department of Biocatalysis and Isotope Chemistry, Almac, 20 Seagoe Industrial Estate, Craigavon, BT63 5QD,, Nuclear Medicine Unit, Department of Clinical and Experimental Internistic , Nuclear Medicine Department, S. Andrea Hospital, La Spezia,, Nuclear Medicine Unit, Department of Clinical and Experimental Internistic
Keywords:Radiometal, radionuclide antibody conjugates, antibody-drug conjugates (ADCs), biovectors, targeted alpha therapy, cancer.
Abstract:Radionuclide antibody conjugates (RACs) and antibody-drug conjugates (ADCs) can function as
biotherapeutic missiles in order to target cancer cells and destroy them. The advent of new technology platforms
consisting of imaging modalities, drug design and radiochemistry will facilitate the personalised approach for cancer
patient treatment programmes. The utilisation of radionuclides and cytotoxic drugs conjugated to biovectors can
deliver a cytotoxic drug payload with the ability to emit alpha and/or beta particles in the vicinity of the tumour by
binding onto the cancer cells surface antigens initiating cell death. This perspective aims to provide an insight into
targeted therapies in the treatment of various cancerous disease states including breast cancer, prostate bone
metastases, lymphoma and leukaemia.
