Suspicion for drug hypersensitivity (DH) is a common reason for children’s referral
to an allergy department, with β-lactam antibiotics and nonsteroidal anti-inflammatory
drugs (NSAIDs) as the most frequently involved drugs. The prevalence of DH in children
remains not well defined as epidemiologic studies in children are lacking, and the most of
those take into account adverse drug reactions (ADR) without a systematic allergy work-up
to confirm or exclude hypersensitivity. The clinical history is mandatory in order to classify
the reaction as being immediate or non-immediate and then to subsequently adapt the allergy
work-up. Mainly due to the lack of studies, the same guidelines used for diagnosis of drug
allergy in adults are generally used in the pediatric population, and the diagnosis is based
mainly on in vivo tests (i.e. skin tests and/or drug provocation test) and rarely on in vitro
tests. However, specific aspects of management of DH in children have been recently highlighted.
Keywords: Drug hypersensitivity, children, β-lactam, nonsteroidal anti-inflammatory drugs, vaccines, allergy diagnosis.
Rights & PermissionsPrintExport