In spite of being the most common primary brain tumor in adults, extracranial
metastases are rarely seen during the lifetime of patients with glioblastoma. Majority of
metastases occur in chest, abdomen, bone, lymph nodes, and spinal cord. Scalp lesions
from glioblastoma are extremely rare, with only few cases reported in the literature. Scalp
glioblastomas have been reported to occur via direct extension of the intracranial tumor
across the craniotomy defect or as a nodule along the surgical approach distinct from the
recurrent intracranial tumor. In the latter presentation, the mechanisms involved are supposed
to be direct tumor cell implantation during the primary surgery or hematogenous
dissemination of tumor cells. We report a case of a 60-year-old man who presented recurrent
scalp lesions from glioblastoma. This illustrative case highlights the importance of
suspicious of disease spread in patients with glioblastoma who present with scalp lesions
after surgery. Also, we review the literature concerning epidemiology, pathogenesis,
treatment, and prognosis.
Keywords: Brain tumors, cutaneous, glioblastoma, metastasis, scalp, skin.
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