Background: Tip60, the founding member of MYST histone acetyltransferase family, was
originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays
roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and
checkpoint control and apoptosis by acetylating its histone or non-histone substrates.
Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers.
Conclusion: Here, main functions and its known inhibitors were summarized.
Keywords: Cancer, ε-amino, HATs, HDACs, histone acetyltransferase, inhibitor, Tip60.
Rights & PermissionsPrintExport