In clinical studies, drugs with hydrophobic characteristic usually reflect low bioavailability, poor drug absorption,
and inability to achieve the therapeutic concentration in blood. The production of poor solubility drugs, in
abundance, by pharmaceutical industries calls for an urgent need to find the alternatives for resolving the above mentioned
shortcomings. Poor water solubility drugs loaded with polymeric micelle seem to be the best alternative to enhance
drugs solubility and bioavailability. Polymeric micelle, formed by self-assembled of amphiphilic block copolymers
in aqueous environment, functioned as solubilizing agent for hydrophobic drug. This review discusses the fundamentals
of polymeric micelle as drug carrier through representative literature, and demonstrates some applications in
various clinical trials. The structure, characteristic, and formation of polymeric micelle have been discussed firstly.
Next, this manuscript focuses on the potential of polymeric micelles as drug vehicle in oral, transdermal routes, and
anti-cancer agent. Several results from previous studies have been reproduced in this review in order to prove the efficacy
of the micelles in delivering hydrophobic drugs. Lastly, future strategies to broaden the application of polymeric
micelles in pharmaceutical industries have been highlighted.