Stem Cell Mobilizers: Novel Therapeutics for Acute Kidney Injury

Author(s): Yue Xu, Song Zeng, Qiang Zhang, Zijian Zhang, Xiaopeng Hu*

Journal Name: Current Protein & Peptide Science

Volume 18 , Issue 12 , 2017

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Graphical Abstract:


In the past decade, rapid developments in stem cell studies have occurred. Researchers have confirmed the plasticity of bone marrow stem cells and the repair and regeneration effects of bone marrow hematopoietic stem cells on solid organs. These findings have suggested the possibility of using bone marrow stem cell mobilizers to repair and regenerate injured organs. Recent studies on the effects of granulocyte colony-stimulating factor (G-CSF) and Plerixafor (AMD3100) on mouse acute kidney injury models have confirmed that the use of bone marrow stem cell mobilizers may be an effective therapeutic measure. This paper summarizes studies describing the effects of G-CSF and AMD3100 on various acute kidney injury models over the past 10 years.

Keywords: Acute kidney injuries, granulocyte colony-stimulating factor, plerixafor, bone marrow stem cells.

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Article Details

Year: 2017
Published on: 08 October, 2017
Page: [1195 - 1199]
Pages: 5
DOI: 10.2174/1389203717666160909123135
Price: $65

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