Aim and objective: Since a wide range of biological and pharmaceutical
activities of barbituric acid, 4-hydroxycoumarin and their derivatives have been
disclosed until now, in the domain of our interest to find newly catalytic routes for
highly efficient synthesis of potentially interesting biologically active organic
compounds, and extension of their areas, herein we introduce a three component
combinatorial reaction based on (N,N-dimethyl)barbituric acid and 4-
Material and method: All starting materials were purchased from Merck chemical
company and were applied without further purifications. Catalytic reaction between
barbituric acid (or N,N-dimethyl barbituric acid), 4-hydroxycoumarin, and a wide
range of aryl aldehydes by employing titanium dioxide nanowires (TiO2 NWs) is successfully
performed under solvent-free conditions at 100 °C, and led efficiently to obtain target products.
Results: From loading above mentioned three component reaction, starting materials in the presence of
catalytic amounts of TiO2 NWs as a key factor were condensed together via three C-C bond formation
to obtain 12 newly prepared compounds. This procedure profits some advantages such as an efficiency,
environmental safety and high recyclability of nano-catalyst.
Conclusion: In this work, by the use of a green adapted method in a condensation three component
reaction catalyzed by TiO2 NWs as an efficient nano-catalyst, some newly prepared products were
prepared in a one pot, and the scope of potentially interesting biologically active organic compounds
which can be duly considered by biologists and pharmacologists was developed.