For many years, the “one target, one drug” paradigm has been the driving force
behind developments in pharmaceutical research. With the recent advances in molecular
biology and genomics technologies, the focus is shifting toward “drug-holistic” systems
based approaches (i.e. systems pharmacology). The integration of large and diverse amount
of data from chemistry and biology coupled with the development and the application of
network-based approaches to cope with these data is the next paradigm of drug discovery.
Systems pharmacology offers a novel way of approaching drug discovery by developing
models that consider the global physiological environment of protein targets and their modification
by drugs. Studying drug action across multiple scales of complexity from molecular
and cellular to tissue and organism levels may help identify new druggable disease genes and
to design new drugs with a better efficacy and clinical safety.
Keywords: Systems pharmacology, biological network, drug, protein-protein interactions, pathways, gene expression, pharmacogenomics,
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