Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms

Author(s): Jerzy Leszek, Elżbieta Trypka, Euphrosyni Koutsouraki, Dimitrios Michmizos, Nagendra Sastry Yarla, Vadim V. Tarasov, Ghulam Md Ashraf, Gjumrakch Aliev*

Journal Name: Current Medicinal Chemistry

Volume 25 , Issue 39 , 2018

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A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

Keywords: Aging, Alzheimer disease, depression, dementia, BDNF late-life depression.

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Article Details

Year: 2018
Page: [5389 - 5394]
Pages: 6
DOI: 10.2174/0929867323666160902152829
Price: $65

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