Polymeric Quaternary Ammonium Compounds: Versatile Antimicrobial Materials

Author(s): Deanna L. Zubris, Kevin P.C. Minbiole, William M. Wuest

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 3 , 2017

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Graphical Abstract:


Polymeric Quaternary Ammonium Compounds (polyQACs) comprise a broad class of materials with applications in medical implants, food processing, and surface sanitizing, amongst many others. These polymeric substances are especially promising due to their potent antibacterial activity and limited hemolytic toxicity. In particular, many polyQACs have superior therapeutic indices and a lower likelihood of developing antibacterial resistance in comparison to their monomers, making them ideal materials for wound dressings, catheters, and other biomedical applications. This review outlines the history and development, previous successes, current state of the research, and future directions of polyQACs in society.

Keywords: Antimicrobial activity, Biofilm, Cationic polymers, Copolymer, Homopolymer, Hydrogel, Polyquaternium, Quaternary ammonium compound.

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Article Details

Year: 2017
Published on: 23 November, 2016
Page: [305 - 318]
Pages: 14
DOI: 10.2174/1568026616666160829155805
Price: $65

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