Natural Compounds A Weapon to Ameliorate Breast Cancer Cells: A Review

Author(s): Ruchi Singh Thakur, Bharti Ahirwar

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 17 , Issue 3 , 2017

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Graphical Abstract:


Breast cancer is the heterogeneous disease and leading cause of death in women, worldwide. It is generally caused by the perturbation of various signaling pathways responsible for cell apoptosis. Due to genetic variability, different signaling pathways are disrupted in different breast cancer patients; so, to overcome this multifaceted condition, the personalized treatment is preferred. Since, various potential targets exist in breast cancer cells; it raised the need of new prospective of lead compounds. A large number of evidences show that, due to the presence of various secondary metabolites in plants, natural compounds are frequently examined for search of new bioactive molecules. This review includes the pathological aspects of breast cancer and the effect of natural compounds on breast cancer cells along with their possible mechanism of action. (Databases searched were PubMed, Science Direct, Web of Knowledge, Scopus, and Google Scholar).

Keywords: Caspase, oncogenesis, apoptosis, prooxidants, arbutin, caffeolquinic acid, polyphenols.

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Article Details

Year: 2017
Page: [374 - 384]
Pages: 11
DOI: 10.2174/1871520616666160826150659
Price: $65

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