Breast cancer is the heterogeneous disease and leading cause of death in women, worldwide. It is generally
caused by the perturbation of various signaling pathways responsible for cell apoptosis. Due to genetic variability,
different signaling pathways are disrupted in different breast cancer patients; so, to overcome this multifaceted
condition, the personalized treatment is preferred. Since, various potential targets exist in breast cancer cells; it raised
the need of new prospective of lead compounds. A large number of evidences show that, due to the presence of various
secondary metabolites in plants, natural compounds are frequently examined for search of new bioactive molecules.
This review includes the pathological aspects of breast cancer and the effect of natural compounds on breast cancer
cells along with their possible mechanism of action. (Databases searched were PubMed, Science Direct, Web of
Knowledge, Scopus, and Google Scholar).
Keywords: Caspase, oncogenesis, apoptosis, prooxidants, arbutin, caffeolquinic acid, polyphenols.
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