Title:miRNA-Dependent Activation of mRNA Translation
VOLUME: 5 ISSUE: 2
Author(s):Wen-Juan Ni and Xiao-Min Leng
Affiliation:Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Henan 453100, People's Republic of China.
Keywords:Cellular circumstance, gene expression, miRNA, sub-cellular location, target site, translational activation.
Abstract:MicroRNAs (miRNAs) are small and important RNA molecules. They
can regulate gene expression at different levels. Although their biogenesis has been
well documented, elucidation of miRNA-dependent activation of mRNA translation
has just begun. Here, we highlighted different patterns of miRNA-dependent activation
of mRNA translation: miRNA can activate mRNA translation through binding
different target sites; in different sub-cellular locations; under different cellular circumstances.
MiRNA-dependent activation of mRNA translation suggests unexpected
functions of miRNA, that could provide new clues in functional studies of
other ncRNAs.
